Insulin-likegrowthfactor1(IGF-1)isproducedprimarilybytheliverasanendocrinehormoneandintargettissuesinaparacrine/autocrinefashion.IGF-1activatestheIGF-1receptor(IGF1R)andtheinsulinreceptortostimulatesystemicbodygrowthandgrowth-promotingeffectsonalmosteverycellinthebody,especiallyskeletalmuscle,cartilage,bone,liver,kidney,nerve,skin,hematopoietic,andlungcells.IGF-1isapotentactivatoroftheAKTsignalingpathway,whichisknowntobeastimulatorofproliferationandaninhibitorofprogrammedcelldeath.TheIGF-1geneislocatedonchromosome12.MaturehumanIGF-1is100%homologouswithbovineandporcineproteins.RecombinantHumanIGF-1ACFisanon-glycosylatedprotein,containing70aminoacids,withamolecularweightof7.7kDa(2-4).
- AccessionNumber:P05019
- Synonyms:SomatomedinC,mechanogrowthfactor,IGF-1A
- Purity:≥96%determinedbyreducingandnon-reducingSDS-PAGEanalysis
- Bioactivity:TheED50istypicallylessthan5ng/mL.ED50isdeterminedbythedose-dependentproliferationofFDC-P1cells.
- Animalcomponent-freeandcarrier-free
- Custompackagingavailable
Forresearchorfurthermanufacturinguseonly.
Alsoavailableinothersizes.
