IL-6isapleiotropiccytokinewithawiderangeofBIOLOGicalactivitiesinimmuneregulation,hematopoiesis,inflammation,andoncogenesis.IL-6signalsthroughacell-surfacetypeIcytokinereceptorcomplexconsistingoftheligand-bindingIL-6Rαchain(CD126),andthesignaltransducingcomponentgp130(CD130).Signaltransductionthroughgp130,thecommonsignaltransducerofcytokinesrelatedtoIL-6,ismediatedbytheJAK–STATpathwayandtheRAS–MAPKpathway.Inadditiontothemembrane-boundreceptor,asolubleformofIL-6R(sIL-6R)hasbeenpurifiedfromhumanserumandurine.ThesIL-6R/IL-6complexcanstimulateneuriteoutgrowthandpromotesurvivalofneurons,andhencemaybeimportantinnerveregenerationthroughremyelination.IL-6isrelevanttomanydiseaseprocessessuchasdiabetes,atherosclerosis,depression,Alzheimer’sdisease,systemiclupuserythematosus,prostatecancer,andrheumatoidarthritis.Thereisaninterestindevelopinganti-IL-6agentsastherapyagainstmanyofthesediseases.Examplesofsuchtherapeuticagentsincludetocilizumab,whichhasbeenapprovedforrheumatoidarthritisandALD518,describedinclinicaltrials(2-5).HumanIL-6isactiveonmouseandratcells.RecombinantHumanIL-6ACFisanon-glycosylatedproteincontaining184aminoacids,withamolecularweightof21kDa.
- AccessionNumber:P05231
- Synonyms:IFN-β2,B-cellDifferentiationFactor,BSF-2,HSF,MGI-2
- Purity:≥95%determinedbyreducingandnon-reducingSDS-PAGE,UVspectroscopyat280nm.
- Bioactivity:TheED50istypicallylessthan1ng/mL.ED50isdeterminedbythedose-dependentproliferationofmouse7TD-1cells.
- Animalcomponent-freeandcarrier-free
- Custompackagingavailable
Forresearchorfurthermanufacturinguseonly.
