ActivinsaremultifunctionalcytokinespartofTGFbetasuper-family.Theyaredimericproteinsofbetasubunitsconnectedbydisulfidebonds.ActivinAisahomodimericproteinoftwoβAchainsandisnotBIOLOGicallyactiveuntiltheN-terminalpro-peptideiscleavedfromeachchain.Activinsareinvolvedinawiderangeofbiologicalactivitiesandproducedbymanycelltypesthroughoutdevelopment.ActivinsinteractwithTypeIandTypeIIreceptorswithintracellularserine/threoninekinasedomainstosignaltoSMADproteinstoregulatecellularprocessessuchascellproliferation,differentiation,woundhealing,apoptosisandmetabolism.HumanActivinAshares100%aminoacidsequenceidentitywithmurine,porcine,bovineandfelineActivin.RecombinanthumanActivinAisanon-glycosylatedhomodimer,containingtwo117aminoacidchains,withatotalmolecularweightof26.2kDa.

•AccessionNumber:P08476•Synonyms:Inhibinbeta-1,FRP,FSH-releasingprotein•Purity:≥95%purity.DeterminedbyHPLC,reducingandnon-reducingSDS-PAGE,andUVspectroscopy•Bioactivity:ED50typically0.5-5ng/mL.ED50determinedbydose-dependentproliferationinhibitionofmouseplasmocytomacelllineMPC-11.•Animalcomponent-freeandcarrier-free•Custompackagingavailable

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