Epidermalgrowthfactor(EGF)isaproteinthatplaysanimportantroleintheregulationofvariouscellprocesses,includingcellproliferation,migration,survival,anddifferentiation.EGFisamemberoftheEGFfamilythatbindstotheEGFRfamilyofreceptors(alsoknownasErbBreceptors).TheErbBreceptorsconsistoffourtransmembranereceptorsbelongingtothereceptortyrosinekinase(RTK)superfamilyandincludesEGFR(ErbB1/HER-1),ErbB2(neu/HER-2),ErbB3(HER-3),andErbB4(HER-4).FunctionalselectivityofEGFfamilymembersisduetodistinctionsintheconformationoftheligandedreceptorandsubsequentdifferencesinthesitesofreceptortyrosinephosphorylationandreceptorcouplingtosignalingeffectors.RecombinantHumanEGFACFisasingle,non-glycosylatedproteincontaining53aminoacids,withamolecularweightof6.2kDa(1-3).
- AccessionNumber:P01133
- Synonyms:Urogastrone,URG
- Purity:≥95%determinedbyHPLC,reducingandnon-reducingSDS-PAGEanalysis,UVspectroscopyat280nm.
- Bioactivity:TheED50istypicallylessthan15pg/mL.ED50isdeterminedbydose-dependentproliferationofBALB/c3T3cells.
- Animalcomponent-freeandcarrier-free
- Custompackagingavailable
Forresearchorfurthermanufacturinguseonly.
Alsoavailableinothersizes.
