IL-4isapleiotropiccytokineproducedmainlybyasubpopulationofactivatedTcellscalledThelper2(Th2).ItisalsoproducedbyThelper1(Th1)cellsandmastcells.BIOLOGicalactivitiesofIL-4aremediatedbyspecificreceptorsexpressedinavarietyofcelltypes(helperTcells,endothelialcells,mastcellsandmacrophages).IL-4hasawiderangeofeffectsonbothhematopoieticcellsandnon-hematopoieticcells,suchassmoothmuscleandepithelialcells.HumanIL-4share50%sequencehomologywithmurineIL-4,butitsactivitiesarespecies-specific;humanIL-4showsnoactivityonmurinecells.RecombinantHumanIL-4isanon-glycosylatedprotein,containing130aminoacidswithamolecularweightof15kDa.

• AccessionNumber:P05112
   
• Synonyms:BcellStimulatingFactor,BSF-1,BCDF,BCGF
   
• Purity:≥95%purity.DeterminedbyHPLC,reducingandnon-reducingSDS-PAGE,andUVspectroscopy
   
• Bioactivity:ED50typicallylessthan0.5ng/mL.ED50determinedbydose-dependentproliferationofhumanTF1cells.
   
• Animalcomponent-freeandcarrier-free
   
• Custompackagingavailable

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